Secondary Structure and Gating Rearrangements of Transmembrane Segments in Rat P2X4 Receptor Channels
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Secondary Structure and Gating Rearrangements of Transmembrane Segments in Rat P2X4 Receptor Channels
P2X receptors are cation selective channels that are activated by extracellular nucleotides. These channels are likely formed by three identical or related subunits, each having two transmembrane segments (TM1 and TM2). To identify regions that undergo rearrangement during gating and to probe their secondary structure, we performed tryptophan scanning mutagenesis on the two putative TMs of the ...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2005
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.200409221